Endocrine Abstracts

State of the art: In pharmacology, human chorionic gonadotropin (hCG) is considered equivalent to luteinising hormone (LH) since both act on the same receptor. Thus, when testicular function needs to be clinically restored (i.e. in case of hypogonadotropic hypogonadism [HH]), hCG is used instead of LH. However, growing evidences showed LH and hCG activate different molecular pathways and offer different outcomes in women undergoing assisted reproduction. The different action b...

Background: Exogenous follicle-stimulating hormone (FSH) administration in male idiopathic infertility showed the most convincing rationale in the face of a clinical efficacy below expectations. It was calculated that 10 to 18 men have to be treated to achieve one pregnancy.Objectives: To assess the effectiveness of FSH administration in male idiopathic infertility in a clinical setting.Methods: A retrospective real-world study was...

Background: Erectile dysfunction (ED) is the most frequent sexual disorder. Although psychological ED (pED) is the most frequent form, vascular ED (vED) is associated with 1.25 times greater risk of developing major cardiovascular diseases. Alongside cardiovascular aspect, the evaluation of patients’ health, measured by the comorbidities number, in relation to the ED aetiology has never been investigated so far.Objectives: To explore the potential r...